Trial Changelog

Source-linked ClinicalTrials.gov change monitoring for investable companies.

965Investable tickers covered
18537Events in last 30 days
14886NCTs touched in last 30 days
2026-01-15 22:52 UTCLast refreshed (UTC)

2026-01-15

No high/medium-impact events.

2026-01-14

16:05
CL
COLGATE PALMOLIVE CO
Status: NOT_YET_RECRUITING → ACTIVE_NOT_RECRUITING — PHASE3
NCT07263698 • Phase 3 • Status: Not yet recruiting → Active, not recruiting
MEDIUM
16:05
SGIOF
SHIONOGI & CO LTD
Locations updated — PHASE2
NCT07214571 • Phase 2
MEDIUM
16:05
FSNUY
Fresenius SE & Co. KGaA
Locations updated — PHASE2
NCT07254637 • Phase 2
MEDIUM
16:05
VRDN
Viridian Therapeutics, Inc.\DE
Status: RECRUITING → ACTIVE_NOT_RECRUITING — PHASE3
NCT07155668 • Phase 3 • Status: Recruiting → Active, not recruiting
MEDIUM
16:05
PFE
PFIZER INC
Locations updated — PHASE1
NCT07086664 • Phase 1
MEDIUM
16:05
PFE
PFIZER INC
Locations updated — PHASE3
NCT05020236 • Phase 3
MEDIUM
16:05
ALNY
ALNYLAM PHARMACEUTICALS, INC.
Status: NOT_YET_RECRUITING → RECRUITING — PHASE3
NCT07223203 • Phase 3 • Status: Not yet recruiting → Recruiting
MEDIUM
16:05
SKYE
Skye Bioscience, Inc.
Primary endpoint added: Change From Baseline in Ocular Hypertension as Measured by Intraocular Pressure (IOP) — PHASE2
NCT06144918 • Phase 2
MEDIUM
16:05
NVS
NOVARTIS AG
Enrollment 106→1 (-99%) — PHASE2
NCT05987176 • Phase 2 • Enrollment 106→1
MEDIUM
16:05
PFE
PFIZER INC
Locations updated — PHASE3
NCT07013474 • Phase 3
MEDIUM
16:05
HSY
HERSHEY CO
Locations updated — NA
NCT06559852 • Na
MEDIUM
16:05
AZN
ASTRAZENECA PLC
Enrollment 116→118 (2%) — PHASE1, PHASE2
NCT06151964 • Phase 1, Phase 2 • Enrollment 116→118
MEDIUM
16:05
TNGX
Tango Therapeutics, Inc.
Enrollment 308→342 (11%) — PHASE1, PHASE2
NCT06188702 • Phase 1, Phase 2 • Enrollment 308→342
MEDIUM
16:05
PFE
PFIZER INC
Enrollment 96→0 (-100%) — PHASE2
NCT06521762 • Phase 2 • Enrollment 96→0
MEDIUM
16:05
PFE
PFIZER INC
Enrollment 60→7 (-88%) — PHASE1
NCT07086664 • Phase 1 • Enrollment 60→7
MEDIUM
16:05
AZN
ASTRAZENECA PLC
Locations updated
MEDIUM
16:05
SKYE
Skye Bioscience, Inc.
Enrollment 152→136 (-11%) — PHASE2
NCT06577090 • Phase 2 • Enrollment 152→136
MEDIUM
16:05
BMY
BRISTOL MYERS SQUIBB CO
Locations updated — PHASE1, PHASE2
NCT07291076 • Phase 1, Phase 2
MEDIUM
16:05
NVO
NOVO NORDISK A S
changed 5
NCT04865770 • Phase 3
MEDIUM
16:05
NVS
NOVARTIS AG
Status: RECRUITING → TERMINATED (The study has closed earlier than planned due to one of the ) — PHASE2
NCT05987176 • Phase 2 • Status: Recruiting → Terminated • Why stopped: The study has closed earlier than planned due to one of the funders decision to withdraw the financial support for the s…
MAJOR
16:05
KYMR
Kymera Therapeutics, Inc.
Locations updated — PHASE2
NCT07217015 • Phase 2
MEDIUM
16:05
AZN
ASTRAZENECA PLC
Locations updated
MEDIUM
16:05
BNTX
BioNTech SE
Locations updated — PHASE1, PHASE2
NCT06827236 • Phase 1, Phase 2
MEDIUM
16:05
AZN
ASTRAZENECA PLC
Locations updated — EARLY_PHASE1
NCT07086404 • Early_Phase 1
MEDIUM
16:05
VTRS
Viatris Inc
Locations updated — PHASE3
NCT07201129 • Phase 3
MEDIUM
16:05
SKYE
Skye Bioscience, Inc.
Study arms updated — PHASE2
NCT06577090 • Phase 2
HIGH
16:05
MRK
Merck & Co., Inc.
Locations updated — PHASE1
NCT07242469 • Phase 1
MEDIUM
16:05
AZN
ASTRAZENECA PLC
Enrollment 40→42 (5%) — PHASE2
NCT05089916 • Phase 2 • Enrollment 40→42
MEDIUM
16:05
PFE
PFIZER INC
Locations updated — PHASE3
NCT06866405 • Phase 3
MEDIUM
16:05
DNTH
Dianthus Therapeutics, Inc. /DE/
Locations updated — PHASE3
NCT06858579 • Phase 3
MEDIUM
16:05
LXRX
LEXICON PHARMACEUTICALS, INC.
Locations updated — PHASE3
NCT06079359 • Phase 3
MEDIUM
16:05
NVO
NOVO NORDISK A S
Locations updated — PHASE3
NCT04865770 • Phase 3
MEDIUM
16:05
FOXA
Fox Corp
Enrollment 39→36 (-8%) — PHASE2
NCT03527108 • Phase 2 • Enrollment 39→36
MEDIUM
16:05
ALNY
ALNYLAM PHARMACEUTICALS, INC.
Locations updated — PHASE3
NCT07223203 • Phase 3
MEDIUM
16:05
PFE
PFIZER INC
Status: RECRUITING → WITHDRAWN (The study was terminated early as no patients were enrolled.) — PHASE2
NCT06521762 • Phase 2 • Status: Recruiting → Withdrawn • Why stopped: The study was terminated early as no patients were enrolled.
MAJOR
16:05
REGN
REGENERON PHARMACEUTICALS, INC.
Locations updated — PHASE1, PHASE2
NCT07187401 • Phase 1, Phase 2
MEDIUM
16:05
SKYE
Skye Bioscience, Inc.
Primary endpoint removed: Part C - The nature, frequency, and severity of treatment-emergent adverse events (TEAEs), including serious adverse events (SAEs) and adverse events of special interest (AESIs) — PHASE2
NCT06577090 • Phase 2
MEDIUM
16:05
APGE
Apogee Therapeutics, Inc.
Locations updated — PHASE2
NCT07003425 • Phase 2
MEDIUM
16:05
BMY
BRISTOL MYERS SQUIBB CO
Locations updated — PHASE3
NCT06869551 • Phase 3
MEDIUM
16:05
SO
SOUTHERN CO
Status: RECRUITING → SUSPENDED (Pending Protocol Amendment Approval) — PHASE1
NCT05989828 • Phase 1 • Status: Recruiting → Suspended • Why stopped: Pending Protocol Amendment Approval
MAJOR
16:05
ATXS
Astria Therapeutics, Inc.
Locations updated — PHASE3
NCT06842823 • Phase 3
MEDIUM
16:05
PFE
PFIZER INC
Locations updated — PHASE1
NCT06215118 • Phase 1
MEDIUM
16:05
VTRS
Viatris Inc
Locations updated — PHASE2
NCT07266090 • Phase 2
MEDIUM
16:05
VERX
Vertex, Inc.
Locations updated — PHASE2
NCT07161037 • Phase 2
MEDIUM
16:05
VTRS
Viatris Inc
Locations updated — PHASE3
NCT06475742 • Phase 3
MEDIUM
16:05
VRDN
Viridian Therapeutics, Inc.\DE
Enrollment 85→87 (2%) — PHASE3
NCT07155668 • Phase 3 • Enrollment 85→87
MEDIUM
16:05
NBIX
NEUROCRINE BIOSCIENCES INC
Locations updated — PHASE3
NCT07196501 • Phase 3
MEDIUM
16:05
NMRA
Neumora Therapeutics, Inc.
Locations updated — PHASE3
NCT06029439 • Phase 3
MEDIUM
16:05
SYK
STRYKER CORP
Locations updated
MEDIUM
16:05
TGTX
TG THERAPEUTICS, INC.
Locations updated
MEDIUM
16:05
AZN
ASTRAZENECA PLC
Locations updated — PHASE1
NCT07201558 • Phase 1
MEDIUM
16:05
PFE
PFIZER INC
Enrollment 190→26 (-86%) — PHASE1
NCT06704724 • Phase 1 • Enrollment 190→26
MEDIUM
16:05
PFE
PFIZER INC
Locations updated — PHASE1
NCT06704724 • Phase 1
MEDIUM
16:05
VRDN
Viridian Therapeutics, Inc.\DE
Locations updated — PHASE3
NCT07155668 • Phase 3
MEDIUM
16:05
BMY
BRISTOL MYERS SQUIBB CO
Locations updated — PHASE1, PHASE2
NCT06090539 • Phase 1, Phase 2
MEDIUM
16:05
ONON
On Holding AG
Enrollment 120→93 (-22%) — NA
NCT05719077 • Na • Enrollment 120→93
MEDIUM
16:05
ACHV
ACHIEVE LIFE SCIENCES, INC.
Primary endpoint added: Percentage of Participants With Vaping Abstinence From Week 9 to 12 — PHASE2
NCT05431387 • Phase 2
MEDIUM

2026-01-13

17:30
LLY
ELI LILLY & Co
Locations updated — PHASE3
NCT07223593 • Phase 3
MEDIUM
17:30
MDT
Medtronic plc
Enrollment 38→48 (26%)
NCT07166341 • Enrollment 38→48
MEDIUM
17:30
PFE
PFIZER INC
Locations updated — PHASE2
NCT07073820 • Phase 2
MEDIUM
17:30
CRNX
Crinetics Pharmaceuticals, Inc.
Locations updated — PHASE2, PHASE3
NCT07159841 • Phase 2, Phase 3
MEDIUM
17:30
ALC
ALCON INC
Enrollment 470→489 (4%) — PHASE3
NCT07082816 • Phase 3 • Enrollment 470→489
MEDIUM
17:30
TAK
TAKEDA PHARMACEUTICAL CO LTD
Locations updated — PHASE3
NCT05156983 • Phase 3
MEDIUM
17:30
RLYB
Rallybio Corp
Status: COMPLETED → TERMINATED (This study was terminated early by the sponsor due to insuff) — PHASE2
NCT06435845 • Phase 2 • Status: Completed → Terminated • Why stopped: This study was terminated early by the sponsor due to insufficient drug exposure to achieve the intended therapeutic eff…
MAJOR
17:30
NTRA
Natera, Inc.
Study arms updated — PHASE1
NCT06529822 • Phase 1
HIGH
17:30
NVS
NOVARTIS AG
Locations updated — PHASE1
NCT07261631 • Phase 1
MEDIUM
17:30
EML
EASTERN CO
Locations updated — PHASE3
NCT03488693 • Phase 3
MEDIUM
17:30
LLY
ELI LILLY & Co
Locations updated — PHASE3
NCT07165028 • Phase 3
MEDIUM
17:30
OGN
Organon & Co.
Status: NOT_YET_RECRUITING → RECRUITING — PHASE3
NCT07265479 • Phase 3 • Status: Not yet recruiting → Recruiting
MEDIUM
17:30
AMGN
AMGEN INC
Locations updated — PHASE3
NCT07213674 • Phase 3
MEDIUM
17:30
CRNX
Crinetics Pharmaceuticals, Inc.
Primary endpoint added: Percentage of Participants Who Maintain Biochemical Response in IGF-1 (≤1.0× the Upper Limit of Normal [ULN]) at the End of the Randomized Control Phase (EOR) — PHASE3
NCT04837040 • Phase 3
MEDIUM
17:30
OGN
Organon & Co.
Locations updated — PHASE3
NCT07265479 • Phase 3
MEDIUM
17:30
ACRS
Aclaris Therapeutics, Inc.
Locations updated — PHASE2
NCT07011706 • Phase 2
MEDIUM
17:30
MRK
Merck & Co., Inc.
Locations updated — PHASE3
NCT07190248 • Phase 3
MEDIUM
17:30
LLY
ELI LILLY & Co
Locations updated — PHASE3
NCT07202884 • Phase 3
MEDIUM
17:30
AZN
ASTRAZENECA PLC
Locations updated
MEDIUM
17:30
NVMI
NOVA LTD.
Enrollment 500→550 (10%) — NA
NCT05084898 • Na • Enrollment 500→550
MEDIUM
17:30
LXRX
LEXICON PHARMACEUTICALS, INC.
Enrollment 18→6 (-67%) — PHASE1, PHASE2
NCT07218887 • Phase 1, Phase 2 • Enrollment 18→6
MEDIUM
17:30
PFE
PFIZER INC
Status: NOT_YET_RECRUITING → WITHDRAWN (Strategic decision to cancel the study based on adjusted cli) — PHASE3
NCT06103734 • Phase 3 • Status: Not yet recruiting → Withdrawn • Why stopped: Strategic decision to cancel the study based on adjusted clinical development plan.
MAJOR
17:30
PFE
PFIZER INC
Enrollment 1280→0 (-100%) — PHASE3
NCT06103734 • Phase 3 • Enrollment 1280→0
MEDIUM
17:30
LLY
ELI LILLY & Co
Locations updated — PHASE3
NCT07174336 • Phase 3
MEDIUM
17:30
NVS
NOVARTIS AG
Locations updated — PHASE3
NCT06744920 • Phase 3
MEDIUM
17:30
LLY
ELI LILLY & Co
Locations updated — PHASE4
NCT06857942 • Phase 4
MEDIUM
17:30
LLY
ELI LILLY & Co
Locations updated — PHASE3
NCT06383390 • Phase 3
MEDIUM
17:30
SNY
Sanofi
Locations updated — PHASE3
NCT06372145 • Phase 3
MEDIUM
17:30
LLY
ELI LILLY & Co
Locations updated — PHASE1, PHASE2
NCT05821959 • Phase 1, Phase 2
MEDIUM
17:30
EW
Edwards Lifesciences Corp
Locations updated — NA
NCT04919980 • Na
MEDIUM
17:30
AZN
ASTRAZENECA PLC
Locations updated — PHASE3
NCT06764186 • Phase 3
MEDIUM
17:30
AZN
ASTRAZENECA PLC
Enrollment 100→101 (1%) — PHASE3
NCT06764186 • Phase 3 • Enrollment 100→101
MEDIUM
17:30
NVS
NOVARTIS AG
Locations updated — PHASE2
NCT07047118 • Phase 2
MEDIUM
17:30
QNCX
Quince Therapeutics, Inc.
Locations updated — PHASE3
NCT06664853 • Phase 3
MEDIUM
17:30
NVS
NOVARTIS AG
Locations updated — PHASE1
NCT07174063 • Phase 1
MEDIUM
17:30
NUVL
Nuvalent, Inc.
Locations updated
MEDIUM
17:30
CHRS
Coherus Oncology, Inc.
Locations updated — PHASE1
NCT06657144 • Phase 1
MEDIUM
17:30
TLX
Telix Pharmaceuticals Ltd
Locations updated — PHASE1
NCT07197645 • Phase 1
MEDIUM
17:30
LLY
ELI LILLY & Co
Locations updated — PHASE3
NCT07213804 • Phase 3
MEDIUM
17:30
AORT
ARTIVION, INC.
Locations updated — NA
NCT07089576 • Na
MEDIUM
17:30
LLY
ELI LILLY & Co
Locations updated — PHASE3
NCT06292013 • Phase 3
MEDIUM
17:30
NVS
NOVARTIS AG
Locations updated — PHASE1, PHASE2
NCT07288359 • Phase 1, Phase 2
MEDIUM
17:30
AZN
ASTRAZENECA PLC
Locations updated
MEDIUM
17:30
SNY
Sanofi
Locations updated — PHASE3
NCT07007962 • Phase 3
MEDIUM
17:30
BRO
BROWN & BROWN, INC.
Primary endpoint removed: Change in Knowledge of Firearm Injuries in the US — NA
NCT04804189 • Na
MEDIUM
17:30
BNTX
BioNTech SE
Study arms updated — PHASE1
NCT05541861 • Phase 1
HIGH
17:30
SNY
Sanofi
Enrollment 1000→1147 (15%) — PHASE2
NCT06676319 • Phase 2 • Enrollment 1000→1147
MEDIUM
17:30
MRK
Merck & Co., Inc.
Locations updated — PHASE2, PHASE3
NCT07266831 • Phase 2, Phase 3
MEDIUM
17:30
NTRA
Natera, Inc.
Enrollment 16→32 (100%) — PHASE1
NCT06529822 • Phase 1 • Enrollment 16→32
MEDIUM
17:30
LYEL
Lyell Immunopharma, Inc.
Locations updated — PHASE1, PHASE2
NCT05826535 • Phase 1, Phase 2
MEDIUM
17:30
MDT
Medtronic plc
Enrollment 50→21 (-58%)
NCT02712515 • Enrollment 50→21
MEDIUM
17:30
ALC
ALCON INC
Status: RECRUITING → ACTIVE_NOT_RECRUITING — PHASE3
NCT07082816 • Phase 3 • Status: Recruiting → Active, not recruiting
MEDIUM
17:30
LLY
ELI LILLY & Co
Locations updated — PHASE1
NCT07213791 • Phase 1
MEDIUM
17:30
NVCR
NovoCure Ltd
Locations updated — PHASE3
NCT06556563 • Phase 3
MEDIUM
17:30
BNTX
BioNTech SE
Locations updated — PHASE3
NCT07173751 • Phase 3
MEDIUM
17:30
SYRE
Spyre Therapeutics, Inc.
Locations updated — PHASE2
NCT07012395 • Phase 2
MEDIUM
17:30
SO
SOUTHERN CO
Locations updated — NA
NCT07262580 • Na
MEDIUM
17:30
SNY
Sanofi
Locations updated — PHASE2
NCT05039840 • Phase 2
MEDIUM

2026-01-12

15:49
BIIB
BIOGEN INC.
Locations updated — PHASE3
NCT06962800 • Phase 3
MEDIUM
15:49
NUVL
Nuvalent, Inc.
Locations updated
MEDIUM
15:49
CDZI
CADIZ INC
Primary endpoint added: Attitudes toward a Healthy Lifestyle
MEDIUM
15:49
AZN
ASTRAZENECA PLC
Locations updated — PHASE1
NCT07015697 • Phase 1
MEDIUM
15:49
BLCO
Bausch & Lomb Corp
Locations updated
MEDIUM
15:49
AZN
ASTRAZENECA PLC
Locations updated — PHASE3
NCT06380751 • Phase 3
MEDIUM
15:49
GILD
GILEAD SCIENCES, INC.
Enrollment 77→34 (-56%) — PHASE4
NCT03696290 • Phase 4 • Enrollment 77→34
MEDIUM
15:49
BMY
BRISTOL MYERS SQUIBB CO
Locations updated — PHASE1
NCT07171983 • Phase 1
MEDIUM
15:49
GILD
GILEAD SCIENCES, INC.
Status: RECRUITING → TERMINATED (Poor recruitment) — PHASE4
NCT03696290 • Phase 4 • Status: Recruiting → Terminated • Why stopped: Poor recruitment
MAJOR
15:49
BHVN
Biohaven Ltd.
Locations updated — PHASE2
NCT07281495 • Phase 2
MEDIUM
15:49
BHVN
Biohaven Ltd.
Locations updated — PHASE2, PHASE3
NCT06309966 • Phase 2, Phase 3
MEDIUM
15:49
GILD
GILEAD SCIENCES, INC.
Locations updated — PHASE2
NCT05629208 • Phase 2
MEDIUM
15:49
IMNN
Imunon, Inc.
Enrollment 50→30 (-40%) — PHASE1, PHASE2
NCT05739981 • Phase 1, Phase 2 • Enrollment 50→30
MEDIUM
15:49
GILD
GILEAD SCIENCES, INC.
Enrollment 33→20 (-39%) — PHASE2
NCT05629208 • Phase 2 • Enrollment 33→20
MEDIUM
15:49
ALC
ALCON INC
Enrollment 161→71 (-56%) — NA
NCT06401551 • Na • Enrollment 161→71
MEDIUM
15:49
REGN
REGENERON PHARMACEUTICALS, INC.
Locations updated — PHASE2
NCT06981325 • Phase 2
MEDIUM
15:49
ALNY
ALNYLAM PHARMACEUTICALS, INC.
Locations updated — PHASE3
NCT03997383 • Phase 3
MEDIUM
15:49
MRK
Merck & Co., Inc.
Enrollment 228→298 (31%) — PHASE1, PHASE2
NCT06780111 • Phase 1, Phase 2 • Enrollment 228→298
MEDIUM

2026-01-11

No high/medium-impact events.

2026-01-10

No high/medium-impact events.

2026-01-09

No high/medium-impact events.