Methodology

Our methodology focuses on transparency and traceability. Each event is derived from public registry data with links back to the source record.

Snapshots

Capture

We capture trial snapshots from ClinicalTrials.gov and AACT on a recurring cadence.

Preserve

Each snapshot is preserved so changes can be inspected later.

Diffs

Normalize

Normalize common fields (status, dates, enrollment, outcomes).

Classify

Classify changes into consistent event types for review.

Scoring

Materiality

Weights severity with phase and enrollment context to prioritize review.

Rationale

Explains why an event was elevated; not a recommendation.

Confidence

Mapping

Low‑confidence sponsor mappings are suppressed by default.

Visibility

Events are labeled when a mapping is uncertain.

Timing caveats

Lag

Registries may update after company communications.

Verification

Use Trial Changelog to detect changes, then confirm with primary sources.